Institute of Vascular Medicine, Peking University Third Hospital
Beijing 100083, P. R. China
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Institute of Vascular Medicine, Peking University Third Hospital |
| Brief Introduction |
¡¡¡¡Institute of Vascular Medicine was found in 1988 and awarded key laboratory of molecular cardiovascular sciences by the Chinese Ministry of Education in 2001 and has taken charge of many important cardiovascular projects of state, such as The project of state major basic development program (973), The Key Projects of National Scientific Funds, etc. Now the Laboratory has become one of the main bases of cardiovascular basic research of our state, and has gained many great scientific and technological achievement of the state, the ministry of Health, the Educational Ministry and Beijing municipality. The work of the laboratory is mostly concerned with the Adrenergic receptors(ARs) in cardiovascular system and molecular pharmacology £¬ including intracellular signal transduction pathways ¡¢ single molecular biology and t he research of genomics and proteomics associated with adrenergic receptors etc. ¡¡¡¡We plan to elucidate the pathogenetic mechanisms of cardiovascular diseases at the levels of gene and protein; and explore its new strategy of protection and treatment.
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Faculty member ¡¡ Qi-De Han M.D. Professor |
¡¡¡¡HAN Qi-de (Chide Han) : He graduated from Shanghai First Medical College in 1968. Since 1982 he has been worked at Beijing Medical University (became Peking University Health Science Center since 2000) and was promoted full professor in 1990. He worked as a visiting scholar at the Department of Pharmacology, Emory University , USA from 1985 to 1987. He is now professor and Director, Institute of Cardiovascular Sciences at Peking University (PKU). Director, Biomedical Interdisciplinary Research Center at PKU. Meanwhile he held the President of PKU Health Science Center. He was elected as a member of Chinese Academy of Science in 1997. ¡¡¡¡Prof. Han has been majoring research on cardiovascular system and molecular pharmacology for more than 20 years and has got important achievements. He took the lead in verification of the hypothesis that a 1-adrenoceptor ( a 1 -AR) contained two subtypes, a 1A and a 1B , by their different pharmacological characteristics. He established the approach to distinguish these two subtypes and revealed different signal transduction mechanisms between them. The results were published in Nature, Molecular Pharmacology and other international journals and got international recognized. He also proved the existence of the third subtype, a 1D -AR in cardiovascular system. Afterwards his study focused on distribution, expression, mediated biological function, regulation, cross-talk with b -adrenoceptors, and pathophysiological alterations of different a 1 -AR subtypes in heart and blood vessels. The results are of important values in exploring the physiological and pathophysiological significance of existence of the multiple subtypes of a 1 -AR in cardiovascular system. ¡¡¡¡Recently he was interested in the study of complexity and single molecular biology. His research work focuses on the net-work control and integrity of gene expressing and signaling of the cardiac adrenoceptor subtypes. He has created a single molecular imaging model in living cells. ¡¡¡¡He has received many top scientific awards in China , including the National Natural Sciences Award, First Class Award from Ministry of Education, HLHL Award, etc . He has published more than 270 scientific papers. Among them over 70 papers were published in international journals. The papers have been cited for over 1800 times by SCI searched journals. The paper published in Nature in 1987 has been cited for more than 780 times. |
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You-Yi Zhang M.D. Ph.D Professor ¡¡¡¡Dr. Zhang Youyi was granted her Ph.D. in Xinjiang Medical University in 1992. She worked in Institute of Vascular Medicine at Peking University Third Hospital as a post-doctoral fellow between 1992 and 1994. She worked as a Post doctornal at the Department of Pharmacology, Emory University , USA from 1999 to 2001. Dr. Zhang is now professor and Associate Director of Institute of Vascular Medicine and the Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education . She also are editors of Acta Physiologica Sinica, Chinese Journal of Pharmacology and Toxicology, etc.
¡¡¡¡As a principle investigator, she was in charge of more than ten grants including ¡® 973' sub-projects that were organized by National Science and technology Department, grants from the National Natural Science Foundation of China. Dr. Zhang has more than one hundred publications.
¡¡¡¡Since 1993, Dr. Zhang's research has been focused on adrenoceptors and cardiovascular disease, especially on distribution, expression, mediated biological function, signal transduction, regulation, cross-talk between adrenoceptors, and pathophysiological alterations of adrenoceptors in heart and blood vessels. Recently she started to work on study of the net-work control and integrity of signalings of the cardiac adrenoceptors as well as single molecular imaging detection in living cells.
Research interest £º 1. Physiological and pathophysiological significance of co-existence of three subtypes of a 1 -adrenoceptor in heart and blood vessels 2. Network control and integrity of cardiovascular remodeling 3. Single molecule study on adrenoceptors in living cells 4. Drug screening of adrenoceptor subtypes
Recent publication:
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Zhi-zhen Lu Director Technical
Education: 1974-1978: B.S, Graduate from Polymer Chemistry, Department of Chemistry, Lanzhou University , Gansu Province, P.R.China
Employment: 2003.01-Present: Associate Director Technical, Institute of Vascular Medicine, the Third Hospital , Peking University , Beijing , China 2001.09-2002.12: Research Assistant, in Department of Biochemistry and Molecular Biology, Oklahoma State University , Stillwater , Oklahoma , USA 1999.06-2001.09: Associate Director Technical, Institute of Vascular Medicine, the Third Hospital , Peking University , Beijing , China 1993.03-1999.06: Engineer, Institute of Vascular Medicine, the Third Hospital , Beijing Medicine University , Beijing , China 1978.08-1985.12: Assistant Technical, Department of Chemistry, Lanzhou University . Gansu Province , P.R.China |
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Yao Song M.D. Assistant professor |
Education 1987.09-1992.07: Bachelor degree of medical science, Department of Medicine, Capital Medical University , Beijing , China 1996.09-1999.07: Master degree of science, Institute of Vascular Medicine , Peking University Third Hospital , Beijing , China 2005.09-present: Ph.D. candidate, Institute of Vascular Medicine , Peking University Third Hospital , Beijing , China
Employment 1992.08-1996.08: Resident, Emergency Department, Chaoyang Hospital , Beijing , China 1999.08-2000.05: Resident, Emergency Department, Chaoyang Hospital , Beijing , China 2000.05-2002.01: Postdoctoral fellow, Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD21224, USA 2002.01-present: Assistant professor, Institute of Vascular Medicine , Peking University Third Hospital , Beijing , China
Research interest 1. Interaction between adrenoceptors and other proteins, such as non-G proteins; 2. Development of new drugs involved in adrenoceptors; 3. Interaction between nitric oxide synthase and other regulating proteins, such as heat shock protein 90, AMPK, etc. |
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Zi-Jian Li Ph.D. Assistant professor |
Education: 2003.09-2005.10: Postdoctor, Institute of Vascular Medicine, Peking University Third Hospital 2000.08-2003.07: Ph.D., Department of Biochemistry and Molecular Biology, Jilin University 1996.08-1999.07: M.D., Department of Biochemistry and Molecular Biology, Jilin University 1989.08-1992.07: Department of Pharmaceutical science, changchun Medical School ¡¡¡¡As a principal investigator or a participant, he has taken charge of more than 10 grants, including the National Natural Science Foundation of China, China Postdoctoral Science Foundation and National Foundation for New Drug Research and Development, etc.. So far, he has more than 30 scientific papers published and 5 China patents applied. In the year of 2005, he achieved a First Class Award from Jilin provincial Science & Technology Progress Award.
Research Interests: • Application proteomics in research of adrenergic receptor • Biological network and pathway analysis of adrenergic receptor • Drug screening of adrenoceptor subtypes Personal Interests: reading, travel. |
Ming Xu M.D. Ph.D. Assistant professor £¨ 1 £© Exploring the nature of behaviors of adrenergic receptors in living cells at the molecular level. £¨ 2 £© Understanding the molecule mechanisms of the transition from the hypertrophy to heart failure.
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